The UC Irvine Department of Otolaryngology seeks a part-time or full-time project scientist with experience in CRISPR to work on inner ear therapeutics in cell culture and animals. The successful candidate should have a background in molecular genetics and will be overseeing the design and implementation of inner ear therapeutics in cell culture and eventually animal models.
Responsibilities include but are not limited to:
• Hands-on experience analyzing DNA/RNAs methods or proteins (ELISA, qPCR, ddPCR, flow cytometry, western blot, and other techniques)
• Proficient in cell-based assays with various readout technologies, such as flow cytometry
• Proficient in molecular biology techniques common in upstream research, including molecular cloning, cector production and titering, processing genomic DNA and RNA for downstream analysis
• Hands-on experience altering the genome of mammalian cells with gene editing and gene delivery techniques using CRISPR-based tools and beyond in viral vectors (AAV, lentiviral, adenovirus, etc) or mRNA
• Develop and execute assays for characterizing CRISPR delivery constructs such as cell type specificity & expression
• Experience in CRISPR work in animals preferred but not required
• Experience with hearing in animals is a plus but not required
• Collaborate across pre-clinical therapeutic groups and externally to drive the advancement of nucleic acid drug components
• Critically evaluate experiment data and communicate scientific findings as verbal presentations and written reports
• Aid in preparing presentations, reports, and journal/conference publications
• Assist with grant applications as needed
Submit your online application and complete curriculum vitae and 3 or more references by logging in to UC Irvine’s RECRUIT System, located at: https://recruit.ap.uci.edu
All applicants of academic positions at the University of California, Irvine must download, complete, sign, and upload the following form with their applications: Sexual Misconduct, Harassment and Discrimination Declaration Form
More information on the department can be found at http://www.ent.uci.edu/
For further information pertaining to this recruitment please contact:
Hamid Djalilian, Professor
333 City Bvld, Suite 525
Orange, California 92868-5386
Phone: 714-456-5591
Fax: 714-456-5747
Qualifications
Basic qualifications (required at time of application) Ph.D. from an accredited university