Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.
We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.
This position will develop and investigate
in vivo models of brain cancer in the context of blood-brain barrier biology and CNS drug delivery. The position does both hands-on laboratory techniques and collaborative coordination with internal and external teams.
Responsibilities
- Generate in vivo models of brain tumors in mice
- Design and conduct hands-on experiments to characterize mouse models utilizing laboratory techniques such as immunohistochemistry, microscopy, ELISA, western blot, RNA extraction, and more
- Design, coordinate, and assist in conducting in vivo mouse experiments with therapeutic candidates to enable lead selection and candidate identification milestones for discovery-stage programs
- Generate, analyze, and interpret data, including detailed documentation in an electronic lab notebook
- Perform research in a dynamic and collaborative environment
- Communicate and present clearly to internal and external teams
Requirements
- PhD or postdoc in neuro-oncology or closely related field
- Experience with rodent handling and basic in vivo techniques
- Hands-on experience developing metastatic brain tumor models, i.e., via intracardiac injections of tumor cells and in vitro explant culture
- Preferred experience with other brain tumor models (e.g., GBM, GEMM, subcutaneous, etc.)
- Highly detailed with problem solving skills
- Motivated, proactive, and organized with strong communication skills and ability to work in a highly collaborative environment
Salary Range: $121,000.00 to $153,000.00 . Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers
This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.
Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.
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