Who we are

Kojin Therapeutics, Inc. is harnessing groundbreaking discoveries in cell-state and ferroptosis biology to develop first-in-class treatments for use in patients with various forms of cancer, as well as cardiovascular, immunologic, hepatic, and degenerative diseases. Named after the Japanese deity that tamed fire for the good of humanity, Kojin is located in Boston's Seaport biotech neighborhood. We have developed a drug-discovery platform that integrates computational chemistry, structural biology, chemical biology, target-informed screening, and mechanism-driven pharmacology to develop small-molecule therapeutics that specifically modulate ferroptosis, a newly discovered form of programmed cell death. Kojin is backed by a strong syndicate of top-tier investors, led by an experienced biotechnology and pharmaceutical-industry leadership team, and driven by creative, dedicated professionals.

Who we are seeking to join our team

Kojin Therapeutics is seeking a highly motivated, skilled, and collaborative scientist to join our growing biology team. The ideal candidate will be proficient in key areas of chemical biology. The candidate should enjoy working in a multi-disciplinary team comprised of biologists, translational pharmacologists, medicinal chemists, enzymologists, and DMPK experts working on the development of novel therapeutics.

Typical responsibilities for this role include:

Developing and applying innovative chemical biology methods to enable target validation and small-molecule characterization, with a focus on chemoproteomics and activity-based protein profiling
Identifying and implementing creative techniques to study covalent ligands
Designing and running experiments to support multiple drug discovery programs in parallel
Preparing samples for proteomic analysis and collaborating closely with our mass spectrometry team on data acquisition and analysis
Generating, analyzing, and interpreting data and communicating results
Supporting day-to-day laboratory needs, including management and maintenance of reagents, organization of inventories, and administrative responsibilities
Supervising research associates and contributing to the coordination of activities at external CROs
Cultivating a work environment focused on scientific excellence, integrity, and collaboration

The ideal candidate will have the following qualifications:

Ph.D. or equivalent experience in Chemical Biology, Molecular Biology, Biochemistry, or a related field
2+ years of postdoctoral experience applying chemical biology and molecular biology techniques to small-molecule drug discovery in an industry or academic setting
Strong background in chemical biology techniques applied to target engagement and functional characterization of ligands in cellular assays
Demonstrated expertise in chemoproteomics, activity-based protein profiling, and characterization of covalent and non-covalent ligands
Familiarity with common molecular and cell biology techniques to support ligand characterization (e.g., western blotting, cell culture, assay development, in vitro viability assays)
Strong publication record demonstrating creative applications of chemical biology approaches to study small-molecule mechanisms of action
Strong analytical and problem-solving skills and the ability to translate high-level scientific ideas into specific experimental plans
Strong organizational skills and capacity to work independently as well as part of a collaborative team
Ability to communicate effectively and present scientific data

More information about Kojin can be found on our website (www.kojintx.com), LinkedIn, and X.

Direct candidates only, no third-party submissions.

Kojin Therapeutics jobs

Staff Scientist I/II, Chemical Biology