Title: Scientist I/II

Company summary:

Amplitude Therapeutics is a seed-staged biotechnology company focusing on developing the next generation of RNAs to fully unlock the therapeutic potential of RNA biology. We are founded by leaders in the RNA and non-viral therapy fields and backed by premier Biotech VCs.

Position summary:

We are seeking a Scientist I/II to join our growing therapeutics team. The key functions for this lab-based role is to design and perform cell-based experiments to assess the performance of our novel RNA molecules and to conduct the end-point assays for various in vivo experiments (e.g. ELISA, MSD, flow cytometry). These experiments will generate proof of concept across various vaccine candidates and other immune cell therapeutic programs. We offer an inclusive, dynamic, and fast-paced work environment, where team members have ample opportunity to make meaningful impact on our mission and shape our growing company.

Key responsibilities:

· Design & conduct cell-based experiments to assess the expression and immunogenicity of novel RNA constructs

· Design & conduct various immunological assays such as ELISA, MSD, western blots, flow cytometry, and RT-qPCR

· Contribute to the advancement of leads internal and collaboration programs.

· Maintain detailed record of experimental protocols and data in electronic lab notebook.

· Collaborate across research teams to facilitate the success of programs.

Qualifications:

· M.S. or Ph.D. in immunology / virology / cellular biology or related field with 4-8 or 0-4 years of relevant experience in industry, respectively.

· Hands on experience with mammalian cell culture, ELISpot, ELISA and Flow Cytometry is required.

· Expertise in primary human cell culture, multi-color flow cytometry, multiplex cytokine detection and functional assays (e.g. proliferation, cytotoxicity) is required

· Experience in vaccines and/or cell therapies (e.g. T cell, HSCs) is required.

· Experience with western blots and/or RT-qPCR is highly desirable.

· Hands on experiments with in vivo (mouse) experiments is desired.

· Ability to troubleshoot and analyze data.

· Ability to adapt to increasing scope and complexity of work.

Amplitude Therapeutics jobs

Scientist I/II, Immunology