Pinetree Therapeutics, Inc. is a biotech startup developing bispecific antibodies for cancer therapy. Our mission is to deliver on the promise of therapeutic antibodies to treat drug resistant cancers and immune disorders and create the next generation of transformative medicines for patients. We are a group of highly motivated, dedicated professionals working collaboratively in a multi-facetted team with the ultimate goal to improve patient care.

Pinetree Therapeutics is located near Fresh Pond in West Cambridge, convenient to public transportation. If you are looking to join a dynamic team serving this ever-important mission, then Pinetree is the place for you!

Pinetree is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Pinetree will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Join us for career training and development, an exceptional work environment, a sense of community, and allow us to reward you for your accomplishments.

The Role

PineTree Therapeutics is actively seeking an Analytics and Purification Scientist to join a biotechnology company focusing on monoclonal, bi-/tri-valent antibodies, purification and analysis to support early discovery and downstream process development. This is an onsite role in the greater Cambridge MA area.

Duties and Responsibilities:

Analytical method development to support monoclonal, bi-/tri-valent antibodies discovery and development
Improve the purification and analysis utilizing equipment and techniques including Protein A AKTA, CEX-FPLC, AEX-FPLC affinity chromatography, RP-HPLC, HIC-HPLC and CEX-HPLC et al
Executing analytical study and protein/antibody purification to support the programs from early discovery to late-stage development
Troubleshoot purification processes for the purification of bi-valent and tri-valent antibodies within discovery or downstream process development
Lead projects from discovery to late-stage development including design of experiment, scheduling, setting up, executing, troubleshooting, and writing up reports
Write, review and revise research batch records, protocols, reports and presentations
Train and mentor junior scientist(s)

Qualifications

Master Degree or Ph.D.’s degree in biochemistry, chemical engineering, bioengineering, biotechnology or other related fields
Master Degree with 3-5 years postgraduate or Ph.D. with 0-3 years postgraduate of hands-on experience with protein and/or antibody analysis, purification, downstream manufacturing or process development in a bio-pharmaceutical environment
Proven hands-on experience utilizing equipment and techniques such as AKTA chromatography and HPLC
Proficiency with column chromatography using affinity, ion-exchange, mixed-mode, and hydrophobic resins.
Expert in protein/antibody biophysiological characterization such as Tm, deamidation / oxidation, hydrophobicity assessment, charge profiling etc
Good to have bioanalytical experience.
Excellent organizational skills with the ability to work on multiple projects at a time.
Strong technical writing skills
Excellent communication skills and presentation skills

Preferred Skills & Experience:

Curiosity and proactive engagement in scientific discussions are essential.
Must be fluent in English, both written and spoken.

Recruitment & Staffing Agencies: Pinetree does not accept unsolicited resumes from any source other than candidates. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Pinetree, and Pinetree will not owe any referral or other fees with respect thereto.

PineTree Therapeutics Inc jobs

Research Assistant

Scientist, Protein/Antibody Purification & Analytics