Description & Requirements

Embedded within the Broad Institute of MIT & Harvard, the Center for the Development of Therapeutics (CDoT) is a highly collaborative organization of professional drug discovery scientists. Our mission is to translate cutting edge biological insights originating from the Broad community into impactful drug discovery projects. We partner with faculty from MIT, Harvard, and the Harvard teaching hospitals together with industry partners in pharmaceutical, biotechnology and venture capital firms to validate druggable targets and identify leads. We combine our deep expertise in drug discovery with the knowledge and unique capabilities of the Broad Institute to address a wide range of disease areas (including oncology, cardiovascular, psychiatry, infectious and rare diseases). We use systematic approaches in genomics, biology, chemistry, and machine learning coupled with the Broad's culture of creativity, risk taking, and open sharing, to successfully advance science and develop new treatments for patients.

We are seeking an energetic and motivated scientist to be part of CDoT’s in vitro affinity reagent platform. The ideal candidate will have experience with affinity reagents (antibodies, scFvs, or nanobodies, etc) ideally across different display technologies (phage, yeast, ribosome) coupled with a passion for technology development and a strong desire to work at scale with automation, with a keen appreciation for operational efficiency. This position will be part of the team responsible for executing on the development of a high throughput version of our affinity reagent platform. The successful candidate will work closely with antibody engineers, automation engineers, biophysicists, data scientists, machine learning engineers, and Subject Matter Experts to align and execute on platform goals. This position is a unique opportunity to help build a high-impact capability within the Broad.

CHARACTERISTIC DUTIES

Designs and executes on, with supervision, the scientific implementation of high throughput in vitro affinity reagent generation as a platform product within CDoT, including, affinity reagent identification and generation and production and characterization of affinity reagents (binding affinity, epitope binning, and functional characterization)
Helps plan, schedule, and coordinate the affinity reagent production process development
Identifies and resolves technical and methodological problems in the affinity reagent scientific protocol and production process. Makes detailed observations, analyzes/documents experimental data, and interprets results
Ensures platform scientific performance adheres to rigorous standards for reproducibility; tracks and communicates metrics of platform performance
Presents results to affinity reagent platform leadership
Contributes to scientific papers, reports, and presentations. May participate in the writing of grant proposals
Keeps current on advances in the field of affinity reagent generation and prediction
Trains, supervises, and mentors junior members of the platform team

Qualifications

PhD degree in Molecular or Cellular Biology or related field with 0+ years of experience.
Experience in affinity reagent discovery and/or engineering
Experience in process development for high-throughput applications
Experience in biophysical and cellular characterization of affinity reagents
Strategic mindset and desire to constantly improve the status quo
Strong analytical skills and the ability to work both independently and as part of a multidisciplinary team
Adept in ambiguous situations, flexible and comfortable making decisions using available data points that can be limited or imperfect
Adaptable to changing priorities while effectively managing multiple commitments
Outstanding interpersonal and communication skills with proven expertise in cultivating cross-collaborative working relationships across an organization and ability to influence at all levels

Broad Institute of MIT and Harvard jobs

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