Industry: Biotechnology
Title: Scientist I, Cell culture
Job ID: SNFIJP00009136
Location: Framingham, MA - 01701
Duration: 12 months contract (+Possibility to extend)
Must Have Skills:
- Seeking 2-4 years of experience depending on education
- Must have professional work experience, in biotech/ pharma industry.
- For MS candidates, we are considering the required years (2-4) as professional work experience only in addition to the degree. For PhD candidates, professional work experience is required.
- Hands on experience/coursework/knowledge in mammalian cell culture process development:
- Experience with mammalian cell cultures (Experience with CHO cells, HEK cells, HeLa cells, CAR-T cells or T-cells, etc), therapeutic molecule production (enzymes, monoclonal antibodies, viral vectors, vaccines or cell therapy) and/or upstream process development (batch, fed-batch or perfusion cultures)
- Coursework/knowledge and preferably past hands-on experience in bioreactor operation (bench scale and/or pilot scale stirred tank bioreactors or wave bioreactors)
Nice to Have:
- 3+ years of relevant experience
- Hands on experience/coursework/knowledge in Process Analytical Technology: Experience with sensor technology (spectroscopy, electrochemical, chromatographic or other), PAT applications (process monitoring or process control), etc.
- Hands on experience/coursework/knowledge in Data Analytics: Potential experience with Statistical, Machine Learning or Deep Learning for regression in predictive models.
Overview:
- As a scientist, the candidate will contribute to the development, characterization, testing and scale-up/down of automated and PAT (Process Analytical Technology) enabled mammalian cell culture process platforms for biotherapeutic manufacturing.
- The goal of this position is to advance innovation in our manufacturing capabilities by developing robust, scalable, automated, and data-driven cell culture processes for ***’s diverse early and late-stage biologics pipeline. The candidate will work in a cross-functional environment and in close collaboration with members from the Cell Culture Development, Process Analytical Technology, Data Sciences, Automation Engineering and Bioanalytics teams
Key responsibilities:
- Develop, characterize, and test an integrated and automated cell culture process platform and associated process strategies through the integration of sensing technology, data analytics and automation.
- Investigate, design, and independently execute research activities using the aforementioned process platform to improve cell culture process performance (productivity and/or product quality), optimize platform workflows and deepen scientific understanding of cell culture production systems.
- Critically evaluate relevant scientific, technological, and regulatory literature to advance the proposed platform and its impact in our early and late-stage biologics pipeline.
- Lead efforts for industrialization and technology transfer of proposed automated cell culture process platform and associated process strategies within ***.
- Responsible for planning, executing, documenting, and interpreting experimental work and results with appropriate supervision and documentation.
- Author high quality scientific and operational documentation and deliver scientific presentations.
Basic qualifications:
- Master’s degree (2-4 years) or PhD degree (0-2 years) in Biotechnology, (Bio)Chemical engineering, Biology, Biochemistry, or a related field.
- Relevant knowledge, coursework and/or hands-on experience in mammalian cell culture process development (e.g., cell biology and biochemistry, cell culture engineering, recombinant protein production, bioreactor engineering, protein product characterization, sterility and aseptic techniques, technology transfer, etc.).
- Strong motivation, curiosity, attention to detail, multitasking ability and active problem-solving and troubleshooting skills.
- Ability to work both independently and in a team-oriented environment with strong project management and communication skills (oral/written).
Preferred Qualifications:
- Relevant knowledge, coursework and/or hands-on experience in Process Analytical Technology (PAT), its applications (process monitoring, control, and supervision) and/or in-line/on-line sensing technology (e.g. Spectroscopy, Optical, Enzymatic, Chromatographic sensors, etc.)
- Knowledge, coursework and/or hands-on experience in process data analytics (multivariate, time series and/or signal processing through statistical/machine learning methods).