About the Company
Pinetree Therapeutics, Inc. is a biotech startup developing bispecific antibodies for cancer therapy. Our mission is to deliver on the promise of therapeutic antibodies to treat drug resistant cancers and immune disorders and create the next generation of transformative medicines for patients. We are a group of highly motivated, dedicated professionals working collaboratively in a multi-facetted team with the ultimate goal to improve patient care. Pinetree Therapeutics is located near Fresh Pond, in West Cambridge.
Job Summary:
We are looking for a Scientist / Senior Scientist to join our team. This individual will lead research
projects focused on the discovery and characterization of bispecific antibodies for protein degradation in
immune-related diseases, with a particular emphasis on fibrosis. This role involves developing immuno-
assays and collaborating with cross-functional teams to drive the mission of advancing therapies for
immune-related diseases.
Key Responsibilities:
• Independently design, develop, and validate novel immuno-assays for characterizing therapeutic
candidates in autoimmune, inflammatory, and fibrotic diseases.
• Lead projects focused on bispecific antibody development targeting immune and fibrotic disease
pathways.
• Design and execute in vitro and in vivo studies to evaluate therapeutic efficacy in immune and fibrotic
diseases.
• Conduct in-depth immune and fibrosis profiling of preclinical models to understand mechanisms of
action and identify disease-specific biomarkers.
• Develop and optimize ex vivo cell-based functional assays using cell lines, primary cells, and whole
blood to support target validation, antibody drug screening, mechanism of action studies, and
biomarker identification in preclinical and IND-enabling spaces.
• Collaborate with cross-functional teams to integrate findings into broader immunology and fibrosis
research and development strategies.
• Stay current on the latest advancements in immunology and fibrosis research, contributing through
publications, patent applications, and presentations.
• Analyze and communicate research data to stakeholders.
Qualifications:
• Ph.D. in Immunology, Fibrosis Research, or a related field with at least 2+ years of relevant industry
experience, or M.S. in Immunology, Fibrosis Research, or related field with 5+ years of relevant
industry experience.
• Proven expertise in immune cell biology, fibrosis, and immune diseases, with experience in ex vivo
immunology and fibrosis-related assays.
• Experience in multi-color flow cytometry for immunophenotyping human cells (from blood or
tissues), assessing immune response, and evaluating cell signaling pathways.
• Experience with immunoassay platforms (e.g., ELISA, Meso Scale Discovery) for measuring analytes in
serum, plasma, supernatant, or cell lysates.
• Familiarity with fibrotic and immune diseases, including current research and drugs in development.
• Strong analytical and problem-solving skills with a record of scientific innovation and publications.
• Excellent communication and collaboration skills.
• Self-motivated scientist who can generate scientific questions and design experiments to address
them.
• Experience in biomarker discovery, platform-synergistic drug combinations, and large data analysis is
a plus.
• Specific experience in fibrosis research, including the identification and validation of fibrotic
biomarkers, development of fibrosis models, and evaluation of therapeutic agents in fibrosis, is highly
desirable.
What We Offer:
- Opportunity to contribute to groundbreaking research in immunology and related diseases.
- Collaborative, inclusive work environment fostering innovation and career development.
- Competitive compensation and comprehensive benefits.
- Pinetree Therapeutics offers·an opportunity to be at the forefront of immuno-oncology research, contributing to the development of next-generation cancer therapies. This is a chance to work in a collaborative, supportive, and inclusive work environment where innovation thrives, and career development is encouraged.
Pinetree is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Pinetree will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Recruitment & Staffing Agencies: Pinetree does not accept unsolicited resumes from any source other than candidates. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Pinetree, and Pinetree will not owe any referral or other fees with respect thereto.